Publications

2023

Derudas, M., O’Reilly, M., Kirkwood, N. K., Kenyon, E. J., Grimsey, S., Kitcher, S. R., Workman, S., Bull, J. C., Ward, S. E., Kros, C. J., & Richardson, G. P. (2023). Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1247324

Thomas, B. ab I., Lewis, H. L., Jones, D. H., & Ward, S. E. (2023). Central Nervous System Targeted Protein Degraders. Biomolecules, 13(8), 1164. https://doi.org/10.3390/biom13081164

Zhou, J., Wang, H., Shu, T., Wang, J., Yang, W., Li, J., Ding, L., Liu, M., Sun, H., Wong, J., Lai, P. B., Tsang, S.-W., Ward, S. E., Chow, K.-L., Sung, J. J., & Sze-Lok Cheng, A. (2023). Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis. IScience, 26(10), 107626. https://doi.org/10.1016/j.isci.2023.107626

2022

An, H., Elvers, K. T., Gillespie, J. A., Jones, K., Atack, J. R., Grubisha, O., & Shelkovnikova, T. A. (2022). A toolkit for the identification of NEAT1_2/paraspeckle modulators. Nucleic Acids Research, 50(20), e119–e119. https://doi.org/10.1093/nar/gkac771

Cockerill, G. S., Angell, R. M., Bedernjak, A., Chuckowree, I., Fraser, I., Gascon-Simorte, J., Gilman, M. S. A., Good, J. A. D., Harland, R., Johnson, S. M., Ludes-Meyers, J. H., Littler, E., Lumley, J., Lunn, G., Mathews, N., McLellan, J. S., Paradowski, M., Peeples, M. E., Scott, C., … Powell, K. (2021). Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. Journal of Medicinal Chemistry, 64(7), 3658–3676. https://doi.org/10.1021/acs.jmedchem.0c01882

Collins, R., Lee, H., Jones, D. H., Elkins, J. M., Gillespie, J. A., Thomas, C., Baldwin, A. G., Jones, K., Waters, L., Paine, M., Atack, J. R., Ward, S. E., Grubisha, O., & Foley, D. W. (2022). Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. Journal of Medicinal Chemistry, 65(20), 13705–13713. https://doi.org/10.1021/acs.jmedchem.2c00751

Gendron, T., Destro, G., Straathof, N. J. W., Sap, J. B. I., Guibbal, F., Vriamont, C., Caygill, C., Atack, J. R., Watkins, A. J., Marshall, C., Hueting, R., Warnier, C., Gouverneur, V., & Tredwell, M. (2022). Multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination. EJNMMI Radiopharmacy and Chemistry, 7(1), 5. https://doi.org/10.1186/s41181-022-00158-z

Koulouris, C. R., Gardiner, S. E., Harris, T. K., Elvers, K. T., Mark Roe, S., Gillespie, J. A., Ward, S. E., Grubisha, O., Nicholls, R. A., Atack, J. R., & Bax, B. D. (2022). Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Communications Biology, 5(1), 346. https://doi.org/10.1038/s42003-022-03264-5

Noble, J. W., & Atack, J. R. (2022). Exploring Calbindin-IMPase fusion proteins structure and activity. Biochemistry and Biophysics Reports, 30, 101266. https://doi.org/10.1016/j.bbrep.2022.101266